hMG 75 IU Human Menopausal Gonadotropin

hMG — Compound Overview

hMG stands for human menopausal gonadotropin, also known as menotropins or menotrophin. It is a preparation containing glycoprotein hormones, rather than a single peptide with one fixed molecular structure.

Menotropins are characterised by follicle-stimulating hormone and luteinising hormone activity, commonly abbreviated FSH and LH. These terms identify the activities measured when describing the preparation.

Structure and Composition

The glycoprotein components of hMG contain protein chains with attached carbohydrate groups. These carbohydrate features, known as glycosylation, contribute to differences in molecular composition and mass.

FSH and LH each have an alpha and a beta subunit. Their alpha subunits share the same amino acid sequence, while their beta subunits differ. The preparation is therefore described through its constituent proteins and measured activities, rather than one amino acid sequence for the entire product.

Because hMG contains a mixture of glycoproteins, assigning a single molecular formula or molecular weight would not accurately describe the complete preparation.

hMG Compound Information

Property	Details
Compound name	Human menopausal gonadotropin
Alternative names	hMG; menotropins; menotrophin
Classification	Gonadotropin glycoprotein preparation
CAS number — menotropins	61489-71-2
Composition	Glycoprotein preparation with FSH and LH activity
Listed strength designation	75 IU
Measurement unit	International Units of biological activity
Amino acid sequence	Multiple protein components; no single sequence for the preparation
Molecular formula	No single formula for the complete preparation
Molecular weight	Varies with component composition and glycosylation

Understanding Compound Specifications

International Units describe biological activity measured against a reference standard. They do not describe the total powder weight in a vial or a recommended dose.

Identity, activity and purity also describe different characteristics. The CAS number identifies the menotropins preparation, while activity testing and analytical measurements provide additional information about the supplied material.

Studies and Additional Info

These published papers are shared as general background on menotropins. They looked at specific medicinal preparations in clinical settings and did not test this product.

• Menotrophin activity and follicular development: clinical research on the FSH and LH activity of menotrophin preparations.
• Highly purified hMG compared with recombinant FSH: a randomised clinical trial comparing two gonadotropin preparations.